The preview talks about some powerful unique abilities that civilizations have. In Civilization Revolution, every civilization has one unique power for each of the four eras and also one overall power. For example, Germany can instantly upgrade units as new technology becomes available, Aztecs can automatically heal even when in enemy territory, while China will enjoy revolt-free cities. It looks like leaders will also bring additional unique abilities, as the article mentions Catherine the Great has incredible home turf defensive bonus and access to cheap riflemen.
Other things mentioned in the preview include leaders speaking in a Sim-like gibberish, Civ-specific music, controls on Xbox 360, resource model (each tile only produces one single resource – production, food or commerce), building courthouse to expand city border, dealing with barbs, technology research, combat merchanics, and more.
Be sure to check out the preview!